Current Issue : April - June Volume : 2018 Issue Number : 2 Articles : 5 Articles
This study protocol aims to explore the effectiveness, safety, and cost-effectiveness of a herbal medication, Gongjindan (GJD), in\npatients with chronic dizziness. This will be a prospective, multicenter, randomized, double-blind, placebo-controlled, parallelgroup,\nclinical trial. Seventy-eight patients diagnosed with Meniere�s disease, psychogenic dizziness, or dizziness of unknown\ncause will be randomized and allocated to either a GJD or a placebo group in a 1 : 1 ratio. Participants will be orally given 3.75 g\nGJD or placebo in pill form once a day for 56 days. The primary outcome measure will be the Dizziness Handicap Inventory\nscore. Secondary outcome measures will be as follows: severity (mean vertigo scale and visual analogue scale) and frequency\nof dizziness, balance function (Berg Balance Scale), fatigue (Fatigue Severity Scale) and deficiency pattern/syndrome (qi blood\nyin yang-deficiency questionnaire) levels, and depression (Korean version of Beck�s Depression Inventory) and anxiety (State-\nTrait Anxiety Inventory) levels. To assess safety, adverse events, including laboratory test results, will be monitored. Further, the\nincremental cost-effectiveness ratio will be calculated based on quality-adjusted life years (from the EuroQoL five dimensions�\nquestionnaire) and medical expenses. Data will be statistically analyzed at a significance level of 0.05 (two-sided). This trial is\nregistered with ClinicalTrials.gov NCT03219515, in July 2017....
Infections caused by Candida albicans, often refractory and with high morbidity and mortality, cause a heavy burden on the public\nhealth while the current antifungal drugs are limited and are associated with toxicity and resistance.Many plant-derived molecules\nincluding compounds isolated fromtraditional Chinesemedicine (TCM) are reported to have antifungal activity through different\ntargets such as cellmembrane, cell wall, mitochondria, and virulence factors.Here,we reviewthe recent progress in the anti-Candida\ncompounds from TCM, as well as their antifungal mechanisms. Considering the diverse targets and structures, compounds from\nTCM might be a potential library for antifungal drug development....
We examined the effects of essential oil from legal (THC <0.2% w/v) hemp variety on the nervous system in 5 healthy volunteers.\nGC/EIMS and GC/FID analysis of the EO showed that the main components were myrcene and ...
Background. Daodi medicinal material is widely used in Chinese herb medication. However, there is a lack of systematic\nmethodology for identifying characteristics associated with good quality and reliable efficacy of Daodi med-material. Purpose.\nThe purpose of this study is to provide some evidence to further substantiate the use of Daodi medicinal materials. Methods. Seven\nrelevant databases were searched before July 2014. Two evaluators were responsible for screening and categorizing the results. The\ndata was analyzed with Microsoft Excel 2007 and SPSS 21.0 statistical software. Results. Overall, 107 articles were systematically\nanalyzed. Of these studies, 55.1% (59/107) focused on the methodology to assess Daodi med-material, and 38.3% (41/107) were\ninterested in med-material ingredients, soil physical and chemical properties, and the geological background system (GBS). Only\n6.5% (7/107) of studies were mainly conducted as clinical trials and animal experiments. Conclusion. Comparisons between Daodi\nand non-Daodi materials have been studied mainly in terms of the ingredients or composition of medical materials, soil physics\nand chemistry, and the GBS, and some identifying methodologies have been created to identify Daodi attributes. Until now, there\nis still no consensus of comparison criteria between Daodi and non-Daodi medicinal material. Only a few studies were conducted\nthrough animal experiments and clinical trials to determine Daodi superiority....
Background.Wushenziye formula (WSZYF) is an effective traditional Chinesemedicine in the treatment of type 2 diabetes mellitus\n(T2DM). Aim. This study aimed to identify the effects and underlying mechanisms ofWSZYF on improving skeletalmuscle insulin\nresistance in T2DM. Methods. An animal model of T2DMwas induced by Goto-Kakizaki diabetes prone rats fed with high fat and\nsugar for 4weeks. Insulin resistancemodel was induced in skeletalmuscle cell.Results. In vivo,WSZYF improved general conditions\nand decreased significantly fasting blood glucose, glycosylated serum protein, glycosylated hemoglobin, insulin concentration, and\ninsulin resistance index of T2DM rats. In vitro, WSZYF enhanced glucose consumption in insulin resistance model of skeletal\nmuscle cell. Furthermore,WSZYF affected the expressions of molecules in regulating T2DM, including increasing the expressions\nof p-IRS1, p-Akt, and GLUT4, reducing PTP1B expression. Conclusion.These findings displayed the potential ofWSZYF as a new\ndrug candidate in the treatment of T2DM and the antidiabetic mechanism of WSZYF is probably mediated through modulating\nthe PTP1B-IRS1-Akt-GLUT4 signaling pathway....
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